August 6, 2023
Trenton Monitor - August 6, 2023 – "The Summer Enrichment program, run at little-to-no cost to families, came about through a donation from The Mike & Patti Hennessy Foundation, an organization dedicated to supporting various life-improving ventures in the areas of health care, educational opportunities and local Christian educational programs.
The foundation “was excited to offer the Diocese of Trenton elementary schools the opportunity to develop summer programming to support COVID-19 learning loss,” said Bonnie Milecki, assistant superintendent of Catholic schools. READ MORE
July 18, 2023
HealthU - July 18, 2023 – “We feel extremely grateful and fortunate for the Hennessy family's confidence in our mission to expand beyond cancer to the pre-cancer and post-cancer space,” says Andre Goy, M.D., M.S., chairman of John Theurer Cancer Center, chief of Lymphoma and physician-in-chief for Oncology. “The precancer space includes reduction of risk factors through lifestyle changes and early detection. In the post-cancer space, the goal is to prevent recurrence either by managing measurable minimal residual disease (MRD) through additional therapy or detecting and managing recurrence much earlier." READ MORE
June 22, 2023
April 11, 2023
JCI Insight – June 22, 2023 – Epigenetic aberrations, including posttranslational modifications of core histones, are major contributors to cancer. Here, we define the status of histone H2B monoubiquitylation (H2Bub1) in clear cell ovarian carcinoma (CCOC), low-grade serous carcinoma, and endometrioid carcinomas. We report that clear cell carcinomas exhibited profound loss, with nearly all cases showing low or negative H2Bub1 expression. Moreover, we found that H2Bub1 loss occurred in endometriosis and atypical endometriosis, which are established precursors to CCOCs. To examine whether dysregulation of a specific E3 ligase contributes to the loss of H2Bub1, we explored expression of ring finger protein 40 (RNF40), ARID1A, and UBR7 in the same case cohort. Loss of RNF40 was significantly and profoundly correlated with loss of H2Bub1. Using genome-wide DNA methylation profiles of 230 patients with CCOC, we identified hypermethylation of RNF40 in CCOC as a likely mechanism underlying the loss of H2Bub1. Finally, we demonstrated that H2Bub1 depletion promoted cell proliferation and clonogenicity in an endometriosis cell line. Collectively, our results indicate that H2Bub1 plays a tumor-suppressive role in CCOCs and that its loss contributes to disease progression. READ MORE
Ferrari et al. H2Bub1 loss is an early contributor to clear cell ovarian cancer progression. JCI Insight. 2023; 8(12):e164995. https://doi.org/10.1172/jci.insight.164995
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about the Foundation and our grantees.
Hackensack Meridian Health - April 11, 2023 - Inspired by his wife’s tenacity and resilience as she fought recurrent ovarian and breast cancer, Mike Hennessy made it his life’s purpose to help improve the life of patients with cancer. As a medical publisher, he never stopped seeking opportunities to educate health care providers and patients to advance oncology care. For Patti Hennessy, her cancer journey led her to challenge oncologists, nurses and other health professionals to take more detailed family histories, to expand the options for individualized therapy and most importantly, to think outside of the box. Patti’s journey with breast and ovarian cancer ended with her passing at age 59, nearly 10 years after she was diagnosed. But her advocacy and vision, shared by her husband Mike who died two years after her in 2021, will live on through Hackensack Meridian Health’s Hennessy Institute for Cancer Prevention and Applied Molecular Medicine: ICAP. READ MORE
March 2, 2023
Edison, NJ – March 2, 2023 – A transformational grant to Hackensack Meridian John Theurer Cancer Center from the Mike & Patti Hennessy Foundation, together with Shannon H. Pulaski, Ashley Hennessy Talamo, Michael Hennessy and Christopher Hennessy, in memory of their parents Mike and Patti Hennessy and in gratitude for the care provided by Andre Goy, M.D., M.S., chairman and director, chief of Lymphoma, and director of Clinical and Translational Cancer Research at John Theurer Cancer Center, will establish the Hennessy Institute for Cancer Prevention and Applied Molecular Medicine. To be located within a new, planned ambulatory facility in Clifton, New Jersey near Hackensack Meridian’s School of Medicine and Center for Discovery and Innovation, the Hennessy Institute’s focus will be on reducing cancer, improving outcomes and preventing recurrence. READ MORE
January 27, 2023
Scientific Reports – January 27, 2023 – Long interspersed element 1 (LINE‑1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high‑grade serous ovarian carcinoma (HGSOC). Here, we report that ORF1p is not only expressed but also released by ovarian cancer and primary tumor cells. Immuno‑multiple reaction monitoring‑mass spectrometry assays showed that released ORF1p is confidently detectable in conditioned media, ascites, and patients’ plasma, implicating ORF1p as a potential biomarker. Interestingly, ORF1p expression is detectable in fallopian tube (FT) epithelial precursors of HGSOC but not in benign FT, suggesting that ORF1p expression in an early event in HGSOC development. Finally, treatment of FT cells with DNA methyltransferase inhibitors led to robust expression and release of ORF1p, validating the regulatory role of DNA methylation in LINE‑1 repression in non‑tumorigenic tissue. READ MORE
Sato, S., Gillette, M., de Santiago, P.R. et al. LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma. Sci Rep 13, 1537 (2023). https://doi.org/10.1038/s41598-023-28840-5
Lawrenceville, NJ – The 9,500-square-foot addition features a number of new labs and innovative spaces for Rider's expanding science programs. On the first floor addition to the building, there is a new greenhouse, a cybersecurity lab, a software engineering lab, an anatomy/physiology lab and accessible restrooms. Also in the space are a number of elements to inspire collaboration and discussion among students and faculty such as an open floor plan with grouped, informal seating and writable walls. The second floor features a newly constructed artificial intelligence space.
"Rider's science programs are rapidly expanding and this project will allow us to meet the needs of our growing curriculum, preparing our students to enter a competitive workforce or pursue graduate studies," Bidle says.